Sally Usdin Yasuda


GUMC Adjunct -- Assistant Professor




Histamine H1-receptors play a role in homeostatic regulation including temperature and feeding, as well as arousal and learning and memory. These receptors are implicated in the therapeutic and toxic effects of many commonly used drugs such as antihistamines, antipsychotics, and antidepressants. I am interested in differences in response to such agents when they are used clinically in humans, as well as the mechanisms for development of tolerance to the effects that are observed. The research in
my laboratory is focused on the regulation of the H1-histamine receptor.

Clinical and basic research efforts currently underway are investigating H1-receptor regulation. Approaches used in the laboratory are receptor binding studies to evaluate alterations in receptor number, histamine-stimulated phosphoinositide breakdown to evaluate alterations in function, and studies of H1-receptor mRNA to evaluate changes in gene transcription following exposure to drugs acting at the H1-receptor. Clinical studies also use mRNA determination to evaluate changes
following drug administration. The regulation of the H1-receptor has implications both in the pathophysiology of disease as well as in therapeutic approaches.