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Nady Celine Golestaneh

Title

Assistant Professor

Department

Ophthalmology
General profile

Portrait

Phone

+1 202-687-4309

Fax

202-687-1823

Location

SW 201A Med-Dent

Bio

Dr. Nady Golestaneh, PhD. is an Assistant Professor at Georgetown University, Department of Ophthalmology and Neurology and Director of Research Department of Ophthalmology.


Aging is an inevitable universal biological process and one of the most complex phenotypes influenced by environment, living habits and genetic background and therefore difficult to study. Golestaneh’s lab is committed to researching how aging mechanisms affect the cells and induce diseases such as age-related macular degeneration (AMD), the leading cause of blindness among people over 55 years of age in the western world. Using patient-specific induced pluripotent stem (iPS) cells Dr. Golestaneh is investigating the mechanisms that induce the AMD and is developing ways to stop this disease from occurring.

Dr. Golestaneh’s innovative work in the area of stem cells research has earned her several prestigious awards, such as Novel and Newsworthy Award from American Society for Cell Biology 2007 and Georgetown University John Eisenberg Memorial Career Development Award 2010, among others.

Dr. Golestaneh joined Georgetown University as Research Associate in 2005 from Johns Hopkins University where she was a postdoctoral fellow. In 2006 she was promoted to Research Assistant Professor in the Department of Biochemistry and Molecular & Cellular Biology and in 2009 she was awarded by NIH and continued her research as an independent researcher and Principal Investigator. Currently she is an Assistant Professor in Department of Ophthalmology and Neurology and Director of Research Department of Ophthalmology. She is investigating what happens to cells during aging and AMD using adult stem cells generated from patients skin that she uses as an in vitro model of disease. Golestaneh’s research has shown that male germline stem cells can become pluripotent capable of differentiating into the three primordial germ layers, offering the possibility of autologous cell-based therapy in degenerative diseases. In parallel, she has shown that the iPS cells can be differentiated into functional retinal pigment epithelium that could be prominent candidates for regeneration therapies in AMD.


In addition to her research on the molecular pathways of AMD, Dr. Golestaneh is also studying cellular aging on a broader level. Here again using the iPS cells from aged donors she studies the genes that are involved in aging process in human. By understanding the genetic and epigenetic modifications during aging, Golestaneh will be able to develop targeted drugs to slow down the human aging process.


Education

  • Postdoctoral fellowship (2004-2005) Johns Hopkins University, Neuroscience
  • Postdoctoral fellowship (2001-2004) NIH, NEI, LMDB
  • PhD (2000) University of Paris VI, Pierre et Marie Curie , Biology and Pharmacology of Aging
  • Master of Science (1995) University of Paris VI, Pierre et Marie Curie, Biology and Pharmacology of Aging
  • Bachelor Degree in Science (1994) University of Paris VII, Jussieu, Biochemistry and Cellular Biology

Languages

  • Farsi (speak, read)
  • French (speak, read, write)