Robert Clarke

Title

Dean of Research
Professor, Department of Oncology Co-Director, Breast Cancer Program

Department

Lombardi Comprehensive Cancer Center (LCCC)
General profile

Portrait

Phone

+1 202-687-9364

Alt. phone

(202) 687-4060

Fax

(202) 687-2085

Bio

An internationally recognized leader in breast cancer research, Dr. Robert Clarke studies how hormones, growth factors, and other related molecules affect breast cancer, and how breast cancers become resistant to hormonal and cytotoxic chemotherapies. He has expertise in the fields of estrogens, antiestrogens, aromatase inhibitors, cell signaling, drug resistance, bioinformatics, and signal transduction.

Dr. Clarke has developed a series of hormone resistant breast cancer models that are now widely used in the field, and he continues to develop new experimental models. He is currently working on the development and application of genomic and novel bioinformatic methods to data from ongoing translational studies in both humans and experimental models. In other research, Dr. Clarke and his colleagues have recently identified a new molecular signaling network in breast cancer that involves several novel oncogenes and suppressor genes. This integrated network incorporates cell stress signaling, protein misfolding, and communication among the endoplasmic reticulum, mitochondria and nucleus of breast cancer cells. Ultimately, this network determines if a breast cancer cell will grow, differentiate or die, and the mechanism by which the cell will die (apoptosis, autophagy, necrosis, senescence), in response to therapy.

Currently, Dr. Clarke leads several multinational molecular medicine studies in breast cancer, in collaboration with Dr. Minetta Liu (Mayo Clinic) and colleagues at Virginia Tech and the University of Edinburgh (Scotland). With Dr. Subha Madhavan at LCCC, he leads an NCI-funded In Silico Research Center of Excellence. Dr. Clarke is regularly invited to speak about his research at international and national meetings. Representative publications from his bibliography can be found elsewhere in this profile. Dr. Clarke recently completed his tenure as Chair of the NIH peer-review study section Basic Mechanisms of Cancer Therapeutics (2011-2013); previously he had served a term as Chair of the Basic Science study section for NIH National Center for Complementary and Alternative Medicine (2002-2008). He also serves on the editorial boards of over a dozen international peer review journals. For example, Dr. Clarke is a Senior Editor for the journal Cancer Research, an Associate Editor for Endocrine-Related Cancer, and a member of the Editorial Boards of over a dozen journals including Clinical Cancer Research, Molecular Cancer Therapeutics, Breast Cancer Research and Treatment, and British Journal of Cancer. Dr. Clarke also is a Fellow of the Royal Society of Chemistry, a Fellow of the Royal Society of Medicine, and a Fellow of the Society of Biology in the U.K.

Interim Director for the Biomedical Graduate Research Organization at Georgetown University Medical Center (GUMC), home to 60% of biomedical research at GUMC, and an Associate Vice President of GUMC, Dr. Clarke is Co-Director (with Dr. Claudine Isaacs) of the Breast Cancer Program (Lombardi Comprehensive Cancer Center). He served as a member of the Georgetown University Faculty Senate (2002-2011) and as Secretary-Treasurer (2004-2007).

Education

  • D.Sc. (1999) The Queen's University of Belfast, UK, Biochemistry
  • Postdoctoral Fellowship (1987-1988) National Cancer Institute, NIH, USA, Breast Cancer
  • Ph.D. (1986) The Queen's University of Belfast, UK, Biochemistry
  • M.Sc. (1982) The Queen's University of Belfast, UK, Biochemistry
  • B.Sc. (1980) University of Ulster at Jordanstown, UK, Biological Sciences