Studies on Chronic Fatigue Syndrome with Gulf War Illness
Our research team is examining proteomic (protein) differences between veterans with Gulf War Illness (GWI) and healthy veterans in hopes of learning more about how GWI works. In our first study, we are also looking at differences in genetics, pain sensitivity, muscular, and autonomic nervous system function between GWI vets and healthy vets. Based on current data, we believe that GWI may be related to a certain genotype for an enzyme (carnosine dipeptidase-1) that degrades two of the body's important antioxidants.
Our second project is a treatment study using Carnosine, one of these antioxidants. If this genetic
difference does contribute to GWI, then replacement of this antioxidant could
provide relief of symptoms.
a previous study, our research team and our research collaborators discovered
some specific proteins in the spinal fluid of CFS and GWI patients. In this study
we will have a larger group of people with and without CFS/GWI and will look
for those and other unique sets of proteins in the spinal fluid and blood using
more sensitive equipment.