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2007-

Our research team is examining proteomic (protein) differences between veterans with Gulf War Illness (GWI) and healthy veterans in hopes of learning more about how GWI works.  In our first study, we are also looking at differences in genetics, pain sensitivity, muscular, and autonomic nervous system function between GWI vets and healthy vets. Based on current data, we believe that GWI may be related to a certain genotype for an enzyme (carnosine dipeptidase-1) that degrades two of the body's important antioxidants.

 

Our second project is a treatment study using Carnosine, one of these antioxidants.  If this genetic difference does contribute to GWI, then replacement of this antioxidant could provide relief of symptoms.

Finally, we are conducting a Chronic Fatigue Syndrome research study.  The CFS study is similar to our GWI study, except that we are also doing lumbar punctures (sometimes called a spinal tap) for the people who participate in this study.  We are doing the lumbar puncture procedure for two reasons:

1)         We believe that increased spinal pressure could be associated with some of the symptoms like recurrent headaches, sleep problems, memory problems, chronic fatigue and pain. For this reason, we measure the spinal fluid pressure during the procedure.

 

2)         During a previous study, our research team and our research collaborators discovered some specific proteins in the spinal fluid of CFS and GWI patients. In this study we will have a larger group of people with and without CFS/GWI and will look for those and other unique sets of proteins in the spinal fluid and blood using more sensitive equipment.

Our hypothesis is that these specific proteins are seen in the spinal fluid of CFS and Gulf war Illness but not in healthy controls and that those proteins will help us understand the cause of these conditions.

If you are interested in participating in one or more of these studies, please contact us at Email Us

 

» More projects for James Nicholas Baraniuk

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