2005-

In this project we will examine the hypothesis that AIB1 plays a critical role in growth factor signaling, driving the development of early preneoplastic lesions (PanIn) in pancreatic cancer. To address this we will use the LSL- KRASG12D model of pancreatic cancer in mice. We will determine if the gain or loss of AIB1 function in the mouse model- a) alters the onset and development of the distinct phases of PanIn by examining the histology and gross cellular changes in the pancreas prior to pancreatic cancer development. b) alters gene expression pathways related to growth factor (IGF-1, EGF HER-2) signaling in the exocrine pancreas prior to and during the development of PanIN and PanCa. Significance: These studies are relevant to understanding early changes in gene expression in the pancreas that drive the development and progression of PanCa. Such information may in future provide targets that are amenable to preventive or diagnostic intervention strategies aimed at early stages of PanIN that could ultimately make this disease survivable.

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