1997-2005

Over the past 10 years we have pursued expression studies, ribozyme targeting studies, molecular cloning of the human gene, the mouse cDNA and gene, and the rat cDNA as well as characterization of the new BP homologue, BP2. In the course of the studies we have characterized the retinoid downregulation of the BP1 gene and have demonstrated its upregulation in some malignant tissues and in models of carcinogenesis. Furthermore, we were able to elucidate molecular mechanisms underlying the transcriptional upregulation of the BP1 gene by tumor promoters and growth factors. A large portion of these studies is published or in press or has been submitted for publication recently. In addition to the evaluation of the function and differential regulation of BP1 we have now initiated more detailed mechanistic studies of the activity of BP1 at the protein structure protein / protein, cellular and whole organism levels. In the next phase of this project we will focus on these aspect. This work is supported mostly through an RO1 (renewed in 2000 for 5 years) and some aspects by a grant from the American Cancer Society and the Breast Cancer Program of the DOD. Both finished in 2001. 06/97 to 05/05 - RO1 CA71508-06 (PI Wellstein 30%): Biology and Pathology of FGF-binding proteins.

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