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Circulating tumor cells: a useful predictor of treatment efficacy in metastatic breast cancer

Liu MC, Shields PG, Warren RD, Cohen P, Wilkinson M, Ottaviano YL, Rao SB, Eng-Wong J, Seillier-Moiseiwitsch F, Noone AM, Isaacs C.. "Circulating tumor cells: a useful predictor of treatment efficacy in metastatic breast cancer." J Clin Oncol. (2009).

PURPOSE: Five or more circulating tumor cells (CTCs) per 7.5 mL of blood predicts for poorer progression-free survival (PFS) in patients with metastatic breast cancer (MBC). We conducted a prospective study to demonstrate that CTC results correlate strongly with radiographic disease progression at the time of and in advance of imaging.

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