Luo X, Gong X, Tang CK. "Suppression of EGFRvIII-mediated proliferation and tumorigenesis of breast cancer cells by ribozyme." International Journal of Cancer 104.6 (2003): 716-721.
We have designed and generated a tumor specific ribozyme targeted to EGFRvIII. This specific EGFRvIII ribozyme is able to effectively cleave EGFRvIII mRNA under physiological conditions in a cell-free system, but does not cleave wild-type EGFR and other EGF-family receptors. While expressing this EGFRvIII-ribozyme in breast cancer cells, EGFRvIII-ribozyme is capable of downregulating endogenous EGFRvIII expression at the mRNA and protein levels. Inhibition of tumorigenesis was observed in EGFRvIII-ribozyme transfectants. The ultimate goal of this approach is to provide a potential treatment for breast cancer by specifically targeting this receptor.
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