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Biochemistry and Molecular and Cellular Biology
The focus of my laboratory is to investigate testicular function using cell biology methodology. Using novel methodology developed in our laboratory, we have investigated the distribution of the androgen receptor in the testis, information that had led to new implications regarding our understanding of androgen regulation of spermatogenesis. Specifically, we have employed Laser Capture Microdissection and Real-Time, Fluorescence-Based Quantitative RT-PCR to unravel the role of androgens in the spermatogenic process. This knowledge may prove useful in designing novel strategies to reinstate spermatogenesis, to limit spermatogenesis specifically in the absence of systemic effects, or to block aberrant division of germ cells and somatic cells of the testis during the cancer state.