Rebecca B Riggins
E412 Research Building
I am an Assistant Professor in the Department of Oncology at the Georgetown University Medical Center (GUMC), and a member of the Breast Cancer Program. My laboratory’s research is focused on understanding how estrogen-related receptors (specifically ERRbeta and ERRgamma) function in cancer. Supported by grants from the American Cancer Society, Susan G. Komen for the Cure, and the NCI, we were the first to demonstrate that estrogen-related receptor gamma (ERRgamma), an orphan nuclear receptor with broad similarity to classical estrogen receptor alpha (ER?), plays a key functional role in the acquisition of Tamoxifen resistance in ER+ breast cancer and is a substrate for ERK/MAPK. Newer studies in my lab, funded by a pilot grant from Partners in Research (a GUMC-affiliated philanthropic organization) are identifying the mechanism(s) by which the acyl hydrazone DY131, a synthetic agonist of ERRbeta/gamma, induces cell cycle arrest and death in models of brain and triple negative breast cancer. In conjunction with classical wet-lab studies, I have also been actively involved with the development of several bioinformatics tools, including the Georgetown Database of Cancer (G-DOC), which my informatics colleagues and I used in a recent publication that identified essential mitosis regulatory networks associated with early distant metastasis in ER+ breast cancer.
- Postdoctoral (2006) Georgetown University, Oncology
- Ph.D. (2003) University of Virginia, Microbiology
- B.A. (1998) Hood College, Biochemistry