Massimo Salvatore Fiandaca


SOM Research Track -- Associate Professor
Departments of Neurology and Neuroscience Co-Director, Biomarker Laboratory and Biorepository (BLaB)


  • General profile
General profile

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At Georgetown, Dr. Fiandaca is primarily responsible for the execution and administration of a variety of funded human research projects investigating blood-based biomarkers related to Alzheimer’s disease (AD), Parkinson’s disease (PD), traumatic brain injury (TBI), autism, and stroke. He serves as chair of one of the Institutional Review Boards and is a member of the Research Integrity Committee.

Dr. Fiandaca had a 25-year career in clinical neurosurgery prior to coming to Georgetown, which featured leadership positions in both academic and private practices. He held previous academic appointments at the University of Massachusetts Medical Center, and the University of Maryland Medical System, including the R. Adams Cowley Shock Trauma Center and Baltimore VA Medical Center. After leaving full time academic neurosurgery in 1993, Dr. Fiandaca became a partner in a neurosurgical group practice serving the Baltimore Maryland region, while maintaining part-time faculty appointments at both the University of Maryland and the Johns Hopkins Affiliated Hospitals. After attending Loyola University’s Sellinger School of Business and Management, and obtaining an MBA in 2001, Dr. Fiandaca started his own private neurosurgical practice in the Baltimore area for the ensuing 11 years, concentrating his practice on complex spinal surgery. Dr. Fiandaca is a Diplomate of the American Association of Neurological Surgeons, Fellow of the American College of Surgeons, and Fellow of the American Association of Neurological Surgeons.

Before joining the Georgetown University Medical Center (GUMC) research faculty in 2012, Dr. Fiandaca was involved in neural transplantation research for PD during the 1980s, during his residency program at Emory University, and via an NIH-sponsored Neuroscience Research Fellowship at the University of Rochester in New York. His neurodegenerative research interests in both PD and AD continued during his academic neurosurgical career and expanded into neurovascular disease and stroke, neuro-oncology, and the direct delivery of therapeutics to the brain. After a research hiatus while in private practice, Dr. Fiandaca resumed his research career via collaboration with a long-time research colleague at UCSF, obtaining a part-time paid research position there from 2006 until the present, working on alternative therapeutic delivery strategies for neurological disorders, including gene therapy for the treatment of PD and liposomes for use in neurooncology. It was through this UCSF research collaboration that Dr. Fiandaca met and began collaborating with Dr. Howard Federoff, culminating in Dr. Fiandaca’s current position as a member of Dr. Federoff’s research team at GUMC.


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  • MBA (2001) Loyola University of Maryland, Business and Management
  • MD (1981) University of Oregon Health Sciences Center (OHSU), Medicine/Surgery
  • BS (1977) Oregon State University, Zoology


  • Italian (speak, read)
  • Spanish (read)