Aykut Uren


Tenure Line -- Professor


Molecular Oncology
General profile





Dr. Aykut Üren started his research career when he was a medical student at Hacettepe University School of Medicine in Ankara, Turkey. During his medical education he took several opportunities abroad to work on the bench, where he learned how to apply basic science to clinical problems. He worked as a special volunteer with Dr. Giovanni Biasi at the University of Padova in Italy (1990) and with Dr. Stuart Aaronson in the Laboratory of Cellular and Molecular Biology at the National Cancer Institute of NIH in Bethesda, Maryland, USA (1991, 1992, 1993). In 1994 he received his MD degree from Hacettepe University and joined the Laboratory of Cellular and Molecular Biology at the National Cancer Institute, where he worked as a postdoctoral fellow for five years. He then worked at the Division of Pediatric Hematology and Oncology at the University of Maryland at Baltimore, Maryland for two years. In 2002 he joined Lombardi Comprehensive Cancer Center at Georgetown University in Washington, DC as an Assistant Professor. In 2010 he was promoted to Associate Professor with tenure. His primary appointment is at the Department of Oncology and his secondary appointment is at the Department of Biochemistry and Molecular & Cellular Biology. His research focuses on molecular mechanisms of malignant transformation. Some of the active projects in his laboratory include investigation of Wnt/beta-catenin signaling in pathogenesis of cervical cancer, development of targeted therapies against EWS-FLI1 oncoprotein in Ewing’s Sarcoma and identification of ezrin mediated molecular pathways in Osteosarcoma metastasis. These studies are currently funded by the National Cancer Institute (R01), Department of Defense and the Children’s Cancer Foundation. He also runs a core facility at the Georgetown University that provides surface plasmon resonance technology thorough Biacore instruments. He teaches tumor biology to graduate students and gross anatomy to medical students, for which has received a Golden Apple Award in 2010. He has 45 publications and 4 patents. He served at study sections for evaluating grant applications from the National Institutes of Health, American Cancer Society, Department of Defense, and European Commission’s 6th Framework Programme for Research. He also served as an ed hoc reviewer for over a dozen international peer review journals including Cancer Research, Clinical Cancer Research, FASEB Journal, Journal of Biological Chemistry, Journal of Clinical Investigation, Molecular and Cellular Biology and Oncogene.


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  • Postdoc (2002) University of Maryland School of Medicine, Pediatric Hematology and Oncology
  • Postdoc (1999) NCI, Molecular and Cellular Biology
  • MD (1994) Hacettepe University School of Medicine, Ankara, T, Medicine


  • Turkish ()